I ascended, then Ctrl+F5ed shortly after, before buying any upgrades or getting any more heavenly chips. I got an error regarding my save in the console, and the game wouldn't load. I eventually had to clear local data, which normally would've ended my 3.5-year run on the game.
Luckily I went into the browser data and was able to retrieve my CC save, but it didn't retain my achievement stats and now I have to re-gain them. Be warned, everyone, export your save before refreshing the game, especially if you've just ascended.